The formation of biodegradable micelles from a therapeutic initiator for enzyme-mediated drug delivery.
نویسندگان
چکیده
The direct grafting of amphiphilic macromolecules by sequential n-carboxyanhydride ring-opening polymerisation (NCA ROP) from a therapeutic initiator enables the formation of monodisperse drug-containing micelles. The subsequent enzyme-mediated hydrolysis of the peptide component permits the programmed release of the encapsulated drug molecules, demonstrating a controlled drug delivery platform that negates any challenging payload loading procedures.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 8 شماره
صفحات -
تاریخ انتشار 2015